Location: US-45 Alt and US 45, Lee Cty Just after MS 41 we’ll enter Lee County and approach US 45 and 278. Location: US 45 Alt and US 45, Lee Cty Exit for US 45 south, US 278 east, and MS 145 north. Stay straight for US 45 north and US 278 west. US 45 … Continue reading U.S. Route 45 Alternate, MS-41 to US-45/US-278/MS-145